Fate or coincidence: do COPD and major depression share genetic risk factors?

摘要: Major depressive disorder (MDD) is a common comorbidity in chronic obstructive pulmonary disease (COPD), affecting up to 57% of patients with COPD. While the COPD and MDD well established, causal relationship between these two diseases unclear. A large-scale electronic health record (EHR) clinical biobank genome-wide association study (GWAS) summary statistics for lung function traits were used investigate potential shared underlying genetic susceptibility MDD. Linkage disequilibrium score regression was estimate correlation phenotypes. Polygenic scores (PRS) developed perform phenome-wide (PheWAS). Multi-trait-based conditional joint analysis identified single nucleotide polymorphisms (SNPs) influencing both We found correlations all small not statistically significant. PRS-MDD significantly associated an increased risk PheWAS (odds ratio [OR] = 1.12, 95% confidence interval [CI]: 1.09-1.16) when adjusting age, sex, ancestry, but this became attenuated controlling smoking history (OR 1.08, CI: 1.04-1.13). No significant associations PRS three SNPs that may contribute traits, which previously mood disorders Our findings suggest observed be driven by strong architecture.