Association of ambient air pollution with the prevalence and incidence of COPD
作者： T. Schikowski , M. Adam , A. Marcon , Y. Cai , A. Vierkotter
DOI: 10.1183/09031936.00132213
关键词: FEV1/FVC ratio 、 Cohort study 、 Environmental health 、 Cohort 、 Obstructive lung disease 、 Vital capacity 、 Physical therapy 、 COPD 、 Medicine 、 Spirometry 、 Incidence (epidemiology)
摘要: The role of air pollution in chronic obstructive pulmonary disease (COPD) remains uncertain. aim was to assess the impact exposure on COPD four cohorts using standardised ESCAPE estimates. Annual average particulate matter (PM), nitrogen oxides (NOx) and road traffic were assigned home addresses land-use regression models. defined by NHANES reference equation (forced expiratory volume 1 s (FEV1)/forced vital capacity (FVC) less than lower limit normal) Global Initiative for Chronic Obstructive Lung Disease criterion (FEV1/FVC <0.70) categorised severity non-asthmatics. We included 6550 subjects with NOx 3692 PM measures. not associated NO2 or PM10 any individual cohort. In meta-analyses only NO2, NOx, indicators positively, although significantly, COPD. statistically significant associations seen females (COPD prevalence GOLD: OR 1.57, 95% CI 1.11-2.23; incidence: 1.79, 1.21-2.68). None principal results significant, weak positive subgroup findings need be evaluated further well followed up longer time, time-matched assignments.
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