A prophylactic low-dose aspirin earlier than 12 weeks until delivery should be considered to prevent preeclampsia.

摘要: Clinical trials and meta-analyses have demonstrated that low-dose aspirin can reduce the risk of preeclampsia fetal growth restriction in high-risk pregnant women. Current obstetric guidelines recommend administration to prevent be initiated after 12 weeks' gestation. This starting time was chosen minimize possible risks maternal bleeding anomalies. However, evidence from reproductive medicine, where is commonly recommended use before early pregnancy, as well existing literature, does not support these concerns. On other hand, defective placentation resulting a subsequent ischemic placenta considered point preeclampsia. Low-dose pregnancy balance levels thromboxane A2 prostacyclin maintain adequate uteroplacental blood flow and, therefore, improve placentation. Thus, an initiation earlier than weeks considered. Meanwhile, shows vascular endothelial function without increasing adverse perinatal outcomes. Therefore, it appears safe prophylactic until delivery.