Novel antineoplastics targeting genetic changes in colorectal cancer.

摘要: Cytotoxic chemotherapy remains the mainstay of medical ­management colorectal cancer (CRC). Research over last two decades has led to a molecular understanding oncogenic mechanisms involved in CRC and contributed rational development antineoplastics that target these mechanisms. During carcinogenesis, genetic changes often occur molecules play key functional roles such as cell proliferation, angiogenesis, apoptosis, death immune-mediated destruction cells. Here, we review novel are approved or for associated with aberrations CRC. Some targeted have proven effective against other solid tumors hold promise treating whereas others now routinely used combination cytotoxic agents. This article reviews CRC, their antitumor mechanisms, stage development.