Necrobiosis lipoidica diabeticorum: response to pentoxiphylline.
作者： S. Basaria , M. Braga-Basaria
DOI: 10.1007/BF03348204
关键词: Diabetes mellitus 、 Coagulative necrosis 、 Angiopathy 、 Dermatology 、 Thrombosis 、 Necrobiosis 、 Etiology 、 Necrobiosis lipoidica 、 Surgery 、 Occlusion 、 Medicine
摘要: Necrobiosis lipoidica diabeticorum (NLD) is a condition that can be physically and psychologically distressing. Angiopathy leading to thrombosis occlusion of the cutaneous vessels has been implicated in its etiology. Pentoxiphylline hemorrheological agent improves blood flow decreases red cell platelet aggregation. Based on these data, aim our study was report clinical course 20-yr-old diabetic woman with NLD during therapy 400 mg 3 times daily. After 1 month therapy, lesions stopped enlarging. months, showed initial signs healing. At 6-month follow-up, there near resolution lesions. The patient continued remained remission at 2-yr follow-up. This improvement relieved psychological stress patient. No side effects treatment were reported. In conclusion, patients may benefit from pentoxiphylline. We recommend drug should for least 6 months.
springer.com
sci-hub.se 参考文章(16)
Marks R, Finlay Ay, Statham B, A randomized double blind comparison of an aspirin dipyridamole combination versus a placebo in the treatment of necrobiosis lipoidica. Acta Dermato-venereologica. ,vol. 61, pp. 270- ,(1981)
ALICE G. HILDEBRAND, NECROBIOSIS LIPOIDICA DIABETICORUM Archives of Internal Medicine. ,vol. 66, pp. 851- 878 ,(1940) , 10.1001/ARCHINTE.1940.00190160068007
Steven R. Quimby, The Cutaneous Immunopathology of Necrobiosis Lipoidica Diabeticorum Archives of Dermatology. ,vol. 124, pp. 1364- 1371 ,(1988) , 10.1001/ARCHDERM.1988.01670090020004
Arja Laukkanen, Jorma E. Fräki, Niilo Väätäinen, Timo Korhonen, Anita Naukkarinen, Necrobiosis lipoidica: Clinical and Immunofluorescent Study Dermatology. ,vol. 172, pp. 89- 92 ,(1986) , 10.1159/000249304
BRUCE J. DUBIN, ERNEST N. KAPLAN, The surgical treatment of necrobiosis lipoidica diabeticorum. Plastic and Reconstructive Surgery. ,vol. 60, pp. 421- 428 ,(1977) , 10.1097/00006534-197709000-00017
Curt M. Littler, Eduardo H. Tschen, Pentoxifylline for necrobiosis lipoidica diabeticorum Journal of The American Academy of Dermatology. ,vol. 17, pp. 314- 316 ,(1987) , 10.1016/S0190-9622(87)80338-9
SIGFRID A. MULLER, Necrobiosis Lipoidica Diabeticorum Archives of Dermatology. ,vol. 93, pp. 272- 281 ,(1966) , 10.1001/ARCHDERM.1966.01600210008002
R. Keith Campbell, Clinical Update on Pentoxifylline Therapy for Diabetes-Induced Peripheral Vascular Disease Annals of Pharmacotherapy. ,vol. 27, pp. 1099- 1105 ,(1993) , 10.1177/106002809302700916
Madalene C. Y. Heng, Moon K. Song, Ming Kiat Heng, Healing of necrobiotic ulcers with antiplatelet therapy. Correlation with plasma thromboxane levels. International Journal of Dermatology. ,vol. 28, pp. 195- 197 ,(1989) , 10.1111/J.1365-4362.1989.TB02465.X
K.C. NOZ, M.J. KORSTANJE, B.J. VERMEER, Ulcerating necrobiosis lipoidica effectively treated with pentoxifylline Clinical and Experimental Dermatology. ,vol. 18, pp. 78- 79 ,(1993) , 10.1111/J.1365-2230.1993.TB00977.X