Sequence-dependent conformation of an A-DNA double helix. The crystal structure of the octamer d(G-G-T-A-T-A-C-C).
作者： Z. Shakked , D. Rabinovich , O. Kennard , W.B.T. Cruse , S.A. Salisbury
DOI: 10.1016/S0022-2836(83)80005-9
关键词: Helix 、 Crystallography 、 A-DNA 、 Glycosidic bond 、 Thymine 、 Histone octamer 、 Stereochemistry 、 Stacking 、 Crystal structure 、 Chemistry 、 Nucleic acid sequence
摘要: The crystal structures of the synthetic self-complementary octamer d(G-G-T-A-T-A-C-C) and its 5-bromouracil-containing analogue have been refined to R values 20% 14% at resolutions 1·8 2·25 A, respectively. molecules adopt an A-DNA type double-helical conformation, which is minimally affected by forces. A detailed analysis structure shows a considerable influence nucleotide sequence on base-pair stacking patterns. In particular, electrostatic interactions between adjacent guanine thymine bases produce symmetric bending double helix major-groove widening. sugar-phosphate backbone appears be only slightly base sequence. local variations in orientation are brought about correlated adjustments torsion angles glycosidic orientation. Sequence-dependent conformational observed here may contribute specificity certain protein-DNA interactions.
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