Liver Resection in Hepatitis B-Related Hepatocellular Carcinoma: Clinical Outcomes and Safety in Overweight and Obese Patients

摘要: Objective and Background Although many studies on evaluating the safety of liver resection in obese patients have been conducted, results remain contradictory. The aim our study was to investigate overweight undergoing for hepatitis B-related hepatocellular carcinoma a large sample. Methods In retrospective cohort with 1543 patients, subjects were stratified into four groups according their body mass index(BMI): obesity(BMI≥28), overweight(BMI:24.0–27.9), normal weight(BMI:18.5–23.9) underweight(BMI<18.5). Dindo–Clavien classification system used grading complications. Clinical characteristics operative outcomes compared among groups. Risk factors postoperative complications evaluated by multivariate analysis. Results According category criteria Working Group Obesity China (WGOC) criteria, 73(4.7%) obese, 412(26.7%) overweight, 982(63.6%) weight 76(4.9%) underweight included cohort. Overweight had more preoperative comorbidities such as hypertension(P<0.001). Mortality, total classified Clavien similar except that fewer However, wound complication common patients(6.3% vs 2.5%,P<0.001,11.0% 2.5%,P = 0.001). Multivariate analysis revealed BMI not an independently significant factor complications. Conclusions Liver is safe itself risk mortality morbidity.