Epigenetic Regulation of Neural Differentiation from Embryonic Stem Cells
作者： Atsushi Shimomura , Eri Hashino
DOI: 10.5772/53650
关键词: Embryonic stem cell 、 Epigenetic regulation of neurogenesis 、 Progenitor cell 、 Neural stem cell 、 Induced stem cells 、 Biology 、 Adult stem cell 、 Cell biology 、 Homeobox protein NANOG 、 Cellular differentiation
摘要: During development, ESCs in the inner cell mass of blastocyst undergo progressive fate restriction and sequentially give rise to tissue-specific multipotent progenitor cells [1-3]. In nervous system, neural (NPCs) are defined as capable differentiating into neurons glia, latter which include astrocytes oligoden‐ drocytes. NPCs sequential during system development [4-6]. early embryonic exclusively neuronal types, however at later stages they differentiate glial types [7, 8]. Understanding how or thus, constitutes a fundamental as‐ pect development.
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