Evaluation of a novel oral iron chelator 1-(N-acetyl-6-aminohexyl)-3-hydroxypyridin-4-one (CM1) for treatment of iron overload in mice
作者： Somdet Srichairatanakool , Kanjana Pangjit , Chada Phisalaphong , Suthat Fucharoen
关键词: Chelation 、 Deferiprone 、 Deferasirox 、 Thalassemia 、 Pharmacology 、 Lipid peroxidation 、 Iron Chelator 、 Chelation therapy 、 Chemistry 、 Malondialdehyde 、 Biochemistry
摘要: Desferrioxamine (DFO), deferiprone (DFP) and deferasirox (DFX) are promising effective iron chelators for the treatment of iron overload in b-thalassemia patients; nonetheless, their side effects have also been reported. 3-Hydroxypyridinone derivatives being developed as a safer new chelator combined chelation therapy. We evaluated the iron-chelating activity 1-(N-acetyl-6-aminohexyl)-3-hydroxypyridin-4-one (CM1) in iron-loaded C57BL6 mice. The feeding a ferrocene-supplemented diet (Fe diet) to mice resulted overload, detectable plasma nontransferrin-bound iron (NTBI) labile (LPI), increases red cell membrane iron, plasma malondialdehyde (MDA) excessive tissue deposits. Like DFP, the CM1 lowered levels non-heme iron, NTBI LPI (p
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