Clinical usefulness and feasibility of time-frequency analysis of chemosensory event-related potentials.

摘要: BACKGROUND: The clinical usefulness of olfactory event-related brain potentials (OERPs) to assess function is limited by the relatively low signal-to-noise ratio responses identified using conventional time-domain averaging. Recently, it was shown that time-frequency analysis obtained EEG signals can markedly improve OERPs in healthy controls, because enhances both phase-locked and non responses. aim present study investigate this approach evaluate its feasibility a setting. METHODOLOGY: We retrospectively analysed recordings from 45 patients (15 anosmic, 15 hyposmic normos- mic). stimulation were joint analysis. ability two methods discriminate between normosmic assessed Receiver Operating Characteristic RESULTS: discrimination performance averaging poor. In contrast, response domain high. Furthermore, we found significant correlation magnitude psychophysical score. CONCLUSION: Time-frequency could be used as an effective reliable diagnostic tool for objective evaluation patients.