Role of upregulated miR-136-5p in lung adenocarcinoma: A study of 1242 samples utilizing bioinformatics analysis

摘要: Abstract Background It is generally acknowledged that miRNAs play pivotal roles in the initiation and development of cancer. The aim current study to investigate clinicopathological role miR-136-5p lung adenocarcinoma its underlying molecular mechanism. Materials methods Data a cohort 1242 samples were provided by Gene Expression Omnibus Cancer Genome Atlas evaluate expression adenocarcinoma. A comprehensive meta-analysis integrating data from all sources was performed, followed summary receiver operating curve plotted appraise upregulated Candidate targets launched intersection differentially expressed genes predicted 12 web-based platforms. Then, hub illustrated protein-protein interaction network. Furthermore, Kyoto Encyclopedia Genes Genomes, Ontology Protein Analysis Through Evolutionary Relationships analyses potential target carried out via bioinformatics tools. Results MiR-136-5p versus normal tissues (standard mean difference = 0.43, 95% confidence interval: 0.27-0.58). characteristic further verified upregulation (area under curve = 0.7459). total 311 candidate gathered create Molecular mechanism analysis unveiled participated cell adhesion molecules, focal adhesion, complement coagulation cascades blood coagulation. Conclusion overexpressed involved suppressing expressions downstream targets, especially claudin-18, sialophorin syndecan 2 participate adhesion.