U.K. Prospective Diabetes Study XV: Relationship of renin-angiotensin system gene polymorphisms with microalbuminuria in NIDDM

摘要: U.K. Prospective Diabetes Study XV: Relationship of renin-angiotensin system gene polymorphisms with microalbuminuria in NIDDM. We performed a case-control study to determine whether molecular variants genes the were associated presence albuminuria non-insulin dependent diabetes mellitus (NIDDM). A total 180 diabetic patients persistent [median urinary albumin (interquartile range) 74 (54 126 mg/liter)] matched two control groups without 7 (5 10) mg/liter] for variables known be raised concentration including hemoglobin A1c and triglyceride. One group was also blood pressure other not, allow assessment interactions hypertension. Association I/D polymorphism ACE M235T variant angiotensinogen (AGT) retinopathy examined. There no significant differences genotype frequency between cases controls or AGT irrespective matching. However, among subjects microalbuminuria, those DD had significantly greater excretion than individuals non-DD 88 (68 170) mg/liter vs. 67 (53 113) mg/liter, P 100 twice upper normal range (60% 38%, P=0.006). When increased occurs, appears higher levels. No association observed.