Reaction of Rat Lungs to Inhaled Chrysotile Asbestos Following Acute and Subchronic Exposures

摘要: Inhalation of asbestos fibers can cause fibrotic and neoplastic diseases in the lung. The early vivo interactions between lung tissue that initiate these have received little study. Male female Fischer 344 rats were placed inhalation chambers exposed to 9.06 ± 1.83 mg/m3 (average respirable mass) chrysotile for 1 hr, day, 7 hrlday 5 days, or days/week 3 months. Qualitative examination showed that, after found not only alveolar macrophages, but also epithelium interstitium region. After months, numerous present interstitium. Morphometric analysis this compartments most significantly changed as a result exposure. majority epithelial changes attributable 57% increase number type II cells 90% their average cell volume. interstitial population in...