Chapter 11 G Protein-Coupled Receptors: Structure and Function of Signal-Transducing Proteins

摘要: Publisher Summary This chapter reviews the knowledge of structure G protein-coupled receptors and structural features that are responsible for various functions ascribed to cell-surface receptors, particularly it emphasizes on β-adrenergic receptor, because it, along with rhodopsin, is most extensively studied receptors. Cell-surface utilize proteins represent a large diverse group proteins. They include many neurotransmitter (e.g, adrenergic, muscarinic cholinergic, serotonergic, peptidergic receptors); pituitary protein hormones, eicosanoids, rhodopsins; pheromone in yeast slime molds. All these integral membrane glycoproteins display significant functional homology. The application molecular cloning techniques study has led elucidation primary several striking aspect presence seven stretches hydrophobic amino acids. In case rhodopsins, biophysical, proteolytic, immunocytochemical, chemical modification experiments have shown regions largely helical span lipid bilayer.