Chapter 26 The prefrontal cortex in schizophrenia and other neuropsychiatric diseases: in vivo physiological correlates of cognitive deficits

摘要: Publisher Summary This chapter discusses the role of prefrontal cortex in schizophrenia and other neuropsychiatric diseases. The human brain, including neuropsychological tests devised to measure aspects cognition—such as mental flexibility concept formation—suggest that, far from being a silent, redundant area, may be at core shaping attitude organizing cognitive repertoire produce highest order goal-directed behaviors. plays fundamental hierarchical organization control consciousness. importance higher cognition behavior is elucidated by observations patients with focal cortical lesions. use vivo functional brain imaging 133Xe inhalation method for measuring regional blood flow (rCBF) study frontal lobe function variety disorders that related dysfunction described chapter. It also focuses on schizophrenia, an illness which considerable heuristic interest impugned.