Urokinase Pulmonary Embolism Trial

作者: Francis Kuthan

DOI: 10.1001/JAMA.1971.03180220083023

关键词: ThrombolysisMedicineSurgeryHeparinUrokinaseStreptokinasePulmonary embolismDiscontinuationThrombusThrombophlebitis

摘要: To the Editor.— A 12-hour infusion of urokinase was shown to accelerate resolution rate pulmonary thromboemboli more than did a similar heparin ( 214: 2163, 1970). However, "... regimen not usually achieve complete thrombolysis...." The lack dramatic thrombolysis may well be ascribed short duration infusion. In study treatment acute thrombophlebitis deep iliac, femoral, and leg veins with streptokinase, Widmer 1 et al showed that it necessary infuse agent for as long three seven days in majority patients treated. conclusions were based exclusively on phlebography, rather upon unreliable clinical signs only. Discontinuation streptokinase effected only after thrombus had been found laboratory tests considerable decrease activity fibrinolytic system,

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