Lin28a transgenic mice manifest size and puberty phenotypes identified in human genetic association studies
作者： Hao Zhu , Samar Shah , Ng Shyh-Chang , Gen Shinoda , William S Einhorn
DOI: 10.1038/NG.593
关键词: LIN28 、 Gene expression profiling 、 Biology 、 Endocrinology 、 Phenotype 、 Genetically modified mouse 、 Locus (genetics) 、 Internal medicine 、 Menarche 、 Genetic association 、 Genetics 、 Transgene
摘要: George Daley and colleagues show that transgenic mice expressing elevated levels of Lin28a have increased body size delayed onset puberty. These findings support human association studies implicating the LIN28B locus in height variation timing menarche.
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