S-Nitrosylation - How Cancer Cells Say NO to Cell Death
作者： Anand Krishnan V. Iyer , Neelam Azad , Liying Wang , Yon Rojanasakul
DOI: 10.1007/978-1-4419-1432-3_5
关键词: Cancer cell 、 Cancer 、 Tumor microenvironment 、 Angiogenesis 、 Tumor progression 、 Cell biology 、 S-Nitrosylation 、 Carcinogenesis 、 Metastasis 、 Biology
摘要: Nitric oxide (NO) is a highly reactive gaseous free radical that regulates various physiological and pathological processes. Of these functions, the role of NO in transformation, growth, metastasis cancers has generated particular interest. However, research describing seems to be conflicting – some studies describe suppressive cancers, while numerous other positive tumor survival progression. In this review, we shall examine roles with focus on how microenvironment phases progression from neoplastic evolution, metastasis. We will also discuss NO-mediated S-nitrosylation, or covalent attachment protein cysteine thiols, carcinogenesis by modulating proteins involved different cancer development.
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