Central mechanisms controlling appetite and food intake in a cancer setting: an update.

摘要: PURPOSE OF REVIEW Cachexia, also known as disease-associated wasting, is an important factor in the mortality of many patients with diseases such cancer, well renal and congestive heart failure. Yet syndrome not yet defined, making diagnosis difficult often subjective on part physician. Nor are central mechanisms cachexia fully elucidated. Recent studies have begun to address these gaps by focusing three areas: role cytokines cachexia, other proteins peptides that might be involved, potential treatments for this devastating syndrome. RECENT FINDINGS Cachexia can caused, absence disease, inflammatory stimuli some chemotherapy drugs, suggesting possible cachexia. Promising include melanocortin antagonism hormones. SUMMARY While more research necessary illuminate causal uncover therapies several its major molecular pathways become elucidated, directions therapeutic approaches.