Altered locus coeruleus-norepinephrine function following single prolonged stress.

摘要: Data from preclinical and clinical studies have implicated the norepinephrine system in development maintenance of post-traumatic stress disorder. The primary source forebrain is locus coeruleus (LC); however, LC activity cannot be directly measured humans, previous research has often relied upon peripheral measures to infer changes central LC-norepinephrine function. To assess function, we single-unit neurons a validated rat model disorder - single prolonged (SPS). We also examined tyrosine hydroxylase mRNA levels SPS control rats as an index utilisation. For electrophysiological recordings, 92 were identified 19 (SPS, 12; control, 7), spontaneous evoked responses noxious event (paw compression) recorded. Baseline restraint stress-evoked expression (n = 16 per group) separate experiment. showed lower but higher responses, leading enhanced signal-to-noise ratio neurons, accompanied by impaired recovery post-stimulus inhibition. In concert, tended at baseline, was exaggerated following stress. These data demonstrate persistent function stress/trauma stress, differences both properties transcription.