Computational Identification of Interaction Motifs in Hepatitis C Virus NS5A and Human Proteins
作者： Mohammed J. Islam , Q. M. Jonathan Wu , Majid Ahmadi , Maher A. Sid-Ahmed
关键词: Molecular biophysics 、 Binding site 、 Computer science 、 Hepatitis C virus 、 Bioinformatics 、 Cellular biophysics 、 Conserved sequence 、 Human proteins 、 Computational biology 、 NS5A
摘要: Identifying binding motifs or critical sequence segments is a key step toward understanding the mechanism of interactions between hepatitis C virus (HCV) and host cell proteins, such as human proteins. In present study, we found pair motifs, G185-L234 in HCV NS5A proteins L-X(3,5)-E-[AEGNQST] which are considered to be determinant for The motif often forms full helix (H) an extended strand-loop (EL) structure. We also 3 highly conserved NS5A, G185-D196, 7^216-^239, S 414-8437, good agreement with experimental results previous studies. These expected prove helpful design high-affinity molecules that target sites
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