Novel antiarrhythmic drugs in atrial fibrillation: focus on tedisamil.
作者： Suresh Krishnamoorthy , Gregory YH Lip
DOI: 10.1517/13543780903114150
关键词: Anesthesia 、 Atrial fibrillation 、 Potassium channel blocker 、 Internal medicine 、 Cardiology 、 Tedisamil 、 Medicine
摘要: Background: Even established and effective antiarrhythmic drugs (AADs) in atrial fibrillation (AF) are limited by their pro-arrhythmic non-target organ side effects. Therefore the search continues for safer new AADs. Objective: This review will examine a novel AAD, tedisamil – multichannel potassium channel blocker its properties, focusing on AF. Methods: Review of literature studies assessing effect humans animal models with arrhythmia(s). Conclusion: Tedisamil appears to be rhythm restoration acute-onset AF patients. The proven anti-ischemic may an added benefit. Further needed confirm safety long-term efficacy.
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