The effect of cyclophosphamide administration on the kidney of the rat
作者： Okamura Takehiko , Emily M. Garland , Rodney J. Taylor , Sonny L. Johansson , Samuel M. Cohen
DOI: 10.1016/0378-4274(92)90089-3
关键词: Kidney 、 Urology 、 Hydroureter 、 Renal papillary necrosis 、 Internal medicine 、 Cyclophosphamide 、 Reflux 、 Medicine 、 Hemorrhagic cystitis 、 Endocrinology 、 Kidney Papillary Necrosis 、 Hydronephrosis
摘要: In studies primarily designed to evaluate the effectiveness of chitosan as a treatment for cyclophosphamide-induced hemorrhagic cystitis in rat, renal papillary necrosis and pyelonephritis were observed. Cyclophosphamide alone produced relatively mild changes. The combination cyclophosphamide intravesical instillation acetic acid induced (38 83% incidence) along with pyelonephritis, hydroureter hydronephrosis. Chitosan, instilled place acid, partially inhibited induction necrosis. It appears that presence vesico-ureteral reflux or without associated hydronephrosis is prerequisite damage.
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