Light-curable polymer/calcium phosphate nanocomposite glue for bone defect treatment.

作者: Oliver D. Schneider , Alexander Stepuk , Dirk Mohn , Norman A. Luechinger , Kirill Feldman

DOI: 10.1016/J.ACTBIO.2010.01.033

关键词: Materials scienceUltimate tensile strengthPhotopolymerAmorphous calcium phosphateCementPolymerComposite materialNanocompositeComposite numberMethacrylate

摘要: Light-curable, methacrylate-based resins are clinically used for complex defect repair in dentistry (Heliobond®). The present study investigates how such easy-to-apply polymers may be on a much broader range of applications, particularly gluing wet bone. We investigate the significantly improved adhesion polymer to bone surfaces close vivo setup using freshly cut cow hip as model. use reactive filler (20 wt.% amorphous, glassy calcium phosphate nanoparticles, a-CaP) allows combination properties (strength; light-curing) and (recrystallization amorphous CaP hydroxyapatite within minutes). This alone has been earlier suggested an injectable cement since it reacts under conditions 10–15 min. Our transfers this reactivity into composite, thus phase establish composite surfaces. Additional vitro bioactivity tests, compressive tensile strength suggest light-curable nanocomposites complex-shaped load-bearing implant materials fracture repair.

参考文章(37)
KS Anseth, SM Newman, CN Bowman, None, Polymeric dental composites : properties and reaction behavior of multimethacrylate dental restorations Advances in Polymer Science. ,vol. 122, pp. 177- 217 ,(1995) , 10.1007/3540587888_16
A CUNEYT TAS, F KORKUSUZ, M TIMUCIN, N AKKAS, An investigation of the chemical synthesis and high-temperature sintering behaviour of calcium hydroxyapatite (HA) and tricalcium phosphate (TCP) bioceramics. Journal of Materials Science: Materials in Medicine. ,vol. 8, pp. 91- 96 ,(1997) , 10.1023/A:1018506800033
Natali B. Bauer, Nina Brinke, Christian Heiss, Agnes B. Skorupa, Fabian Peters, Ralf Kraus, Reinhard Schnettler, Andreas Moritz, Biodegradable β-Tri-Calciumphosphate/hydroxyethyl methacrylate enhanced three component bone adhesive demonstrates biocompatibility without evidence of systemic toxicity in a rabbit model† Journal of Biomedical Materials Research Part B. ,vol. 90, pp. 767- 777 ,(2009) , 10.1002/JBM.B.31346
Max E Valentinuzzi, Magnetotherapy, alternative medicines, Hippocratic oath Biomedical Engineering Online. ,vol. 7, pp. 1- 3 ,(2008) , 10.1186/1475-925X-7-1
Jamie L. Ifkovits, Jason A. Burdick, Review: photopolymerizable and degradable biomaterials for tissue engineering applications. Tissue Engineering. ,vol. 13, pp. 2369- 2385 ,(2007) , 10.1089/TEN.2007.0093
K. Rezwan, Q.Z. Chen, J.J. Blaker, Aldo Roberto Boccaccini, BIODEGRADABLE AND BIOACTIVE POROUS POLYMER/INORGANIC COMPOSITE SCAFFOLDS FOR BONE TISSUE ENGINEERING Biomaterials. ,vol. 27, pp. 3413- 3431 ,(2006) , 10.1016/J.BIOMATERIALS.2006.01.039
Janaina Habib Jorge, Eunice Teresinha Giampaolo, Ana Lúcia Machado, Carlos Eduardo Vergani, Cytotoxicity of denture base acrylic resins: a literature review The Journal of Prosthetic Dentistry. ,vol. 90, pp. 190- 193 ,(2003) , 10.1016/S0022-3913(03)00349-4
I. Sideridou, V. Tserki, G. Papanastasiou, Effect of chemical structure on degree of conversion in light-cured dimethacrylate-based dental resins Biomaterials. ,vol. 23, pp. 1819- 1829 ,(2002) , 10.1016/S0142-9612(01)00308-8
Stefan Loher, Wendelin J. Stark, Marek Maciejewski, Alfons Baiker, Sotiris E. Pratsinis, Dennis Reichardt, Fabrice Maspero, Frank Krumeich, Detlef Günther, Fluoro-apatite and calcium phosphate nanoparticles by flame synthesis Chemistry of Materials. ,vol. 17, pp. 36- 42 ,(2005) , 10.1021/CM048776C