Racial differences in parathyroid hormone levels in patients with secondary hyperparathyroidism.

摘要: AIM African-Americans (AA) with normal renal function have higher parathyroid hormone (PTH) levels than Caucasians (C). This difference was also noted in cross-sectional studies of patients on dialysis. In this study, we evaluated end-stage disease who just began dialysis and were not receiving any vitamin D therapy. METHODS A total 363 recruited (C: 260; AA: 103). All had serum calcium, phosphorus, alkaline phosphatase intact PTH (iPTH) measured within 3 months initiating RESULTS Serum significantly AA vs. C (383 +/- 33 246 19, p < 0.001). present despite similar phosphorus between the 2 groups regardless gender or diabetes status. However, younger 47 years age both groups. CONCLUSION ESRD over are compared to C. The is, part, due an age-dependent reduction seen only Further needed understand mechanisms these racial differences verify whether they mirror alterations at level end-organ tissue.