Influence of the preparation method on the physicochemical properties of indomethacin and methyl-β-cyclodextrin complexes

作者: Shashi Ravi Suman Rudrangi , Ruchir Bhomia , Vivek Trivedi , George J. Vine , John C. Mitchell

DOI: 10.1016/J.IJPHARM.2015.01.010

关键词: CrystallinityDifferential scanning calorimetryDissolution testingDissolutionChemistryChemical engineeringSpray dryingOrganic chemistrySolubilityAqueous solutionSupercritical carbon dioxide

摘要: … The co-evaporated and freeze dried complexes had a lower … by spray drying and supercritical carbon dioxide processing … , was a comparatively rapid process and produced highly …

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