Prolactinoma in a diabetic dialysis patient with erectile dysfunction: a difficult differential diagnosis.

作者: Giorgina B. Piccoli , Francesca Bermont , Andrea Magnano , Giorgio Soragna , Massimo Terzolo

DOI: 10.1900/RDS.2006.3.200

关键词: ProlactinomaVascular diseasePediatricsMedicineDifferential diagnosisSurgeryHemodialysisDiabetes mellitusPopulationRenal replacement therapyErectile dysfunction

摘要: Dialysis patients often suffer from erectile dysfunction. The prevalence of this symptom in the context dialysis is as high 90%. Diabetes, diffuse vascular disease and pharmacological therapy are attendant causes condition, severely impairing quality life. Due to frequency dysfunction uremic patients, minimalist diagnostic approaches used. Nevertheless, a careful differential diagnosis also warranted well dialyzed identify corrigible patterns. case reported here exemplifies critical issue. A 44 year old obese diabetic patient complained about recent onset On examination, penile echo-Doppler was normal, suggested cause other than dia-betic disease. efficiency (daily hemodialysis, flexible schedules, EKRc 15 25 ml/min) same work-up would adopted for non-uremic patients. Whilst rising prolactine level (76.1 µg/l 129 ng/ml) still range commonly found nuclear magnetic resonance examination carried out led identification prolactinoma. Therapy with cabergoline effective sexual potency restored. Normalization hormonal patterns followed within 2 months. This first so far daily patient. It underlines importance non-minimalist approach problem disorders renal replacement (RRT) at least when rapid. suggests considering prolactinoma an emerging general population, which can be detected by use sensitive imaging techniques condition.

参考文章(31)
Atkins Rc, de Kretser Dm, Holdsworth, A comparison of hemodialysis and transplantation in reversing the uremic disturbance of male reproductive function. Clinical Nephrology. ,vol. 10, pp. 146- 150 ,(1978)
Albert Sokol, Milton E. Rubini, Thomas Gral, Some medical problems of chronic hemodialysis. California medicine. ,vol. 107, pp. 236- 246 ,(1967)
Kuerner B, Heidland A, Kokot F, Zech M, Schaefer Rm, Normalization of serum prolactin levels in hemodialysis patients on recombinant human erythropoietin. International Journal of Artificial Organs. ,vol. 12, pp. 445- ,(1989)
Susie Q. Lew, Beth Piraino, Quality of life and psychological issues in peritoneal dialysis patients. Seminars in Dialysis. ,vol. 18, pp. 119- 123 ,(2008) , 10.1111/J.1525-139X.2005.18215.X
Henry A Feldman, Catherine B Johannes, Carol A Derby, Ken P Kleinman, Beth A Mohr, Andre B Araujo, John B McKinlay, None, Erectile dysfunction and coronary risk factors: prospective results from the Massachusetts male aging study. Preventive Medicine. ,vol. 30, pp. 328- 338 ,(2000) , 10.1006/PMED.2000.0643
Y. Ramot, M. J. Rapoport, P. Hagag, A. J. Wysenbeek, A study of the clinical differences between women and men with hyperprolactinemia Gynecological Endocrinology. ,vol. 10, pp. 397- 400 ,(1996) , 10.3109/09513599609023603
S.G. Massry, D.A. Goldstein, W.R. Procci, O.A. Kletzky, Impotence in Patients with Uremia Nephron. ,vol. 19, pp. 305- 310 ,(1977) , 10.1159/000180907
Jayant Dey, Mark Devin Shepherd, Evaluation and Treatment of Erectile Dysfunction in Men With Diabetes Mellitus Mayo Clinic Proceedings. ,vol. 77, pp. 276- 282 ,(2002) , 10.4065/77.3.276
LucyD. Antoniou, Telechery Sudhakar, RobertJ. Shalhoub, J.C. Smith, REVERSAL OF URÆMIC IMPOTENCE BY ZINC The Lancet. ,vol. 310, pp. 895- 898 ,(1977) , 10.1016/S0140-6736(77)90832-7