The protective effect of glucose-insulin-potassium on the response to atrial pacing.
作者： M A Chiong , R West , J O Parker
关键词: Heart rate 、 Internal medicine 、 Asymptomatic 、 Atrial pacing 、 Coronary artery disease 、 Cardiology 、 Insulin 、 Hemodynamics 、 Angina 、 ST depression 、 Anesthesia 、 Medicine
摘要: The effects of glucose-insulin-potassium infusion (GIK) on atrial pacing-induced angina, ST depression, abnormal left ventricular end-diastolic pressure during pacing interruption (LVEDPi) and lactate metabolism (L), were studied in 18 patients: ten had angina = Ischemic group, eight (5 normals 3 with coronary artery disease) remained asymptomatic Nonischemic group. study consisted 8-10 minute periods control, recovery, before after GIK. No untoward observed. Comparison the responses (GIK vs pre-GIK states) showed that GIK, occurred only 4 patients, while significantly less severe changes observed depression (1.4 +/-0.5 2.4 +/- 0.4 mm) LVEDPi (16 23 mm Hg). Lactate extraction was also higher (8.1 10.9 -5.2 11.1%), but not so, although L became normal subjects improved another. These results indicate GIK well tolerated a beneficial effect myocardial ischemia.
sci-hub.se 参考文章(35)
P. Libby, M. Ashraf, P. R. Maroko, H. D. Sybers, E. Braunwald, The Effect of Glucose-Insulin-Potassium on Cardiac Ultrastructure Following Acute Experimental Coronary Occlusion American Journal of Pathology. ,vol. 70, pp. 401- 420 ,(1973)
D. J. Hearse, E. B. Chain, The role of glucose in the survival and `recovery' of the anoxic isolated perfused rat heart Biochemical Journal. ,vol. 128, pp. 1125- 1133 ,(1972) , 10.1042/BJ1281125
Demetrio Sodi-Pallares, Mario R. Testelli, Bernardo L. Fishleder, Abdo Bisteni, Gustavo A. Medrano, Charlotte Friedland, Alfredo De Micheli, Effects of an intravenous infusion of a potassium-glucose-insulin solution on the electrocardiographic signs of myocardial infarction The American Journal of Cardiology. ,vol. 9, pp. 166- 181 ,(1962) , 10.1016/0002-9149(62)90035-8
Gerald F. Fletcher, J.Willis Hurst, Robert C. Schlant, “Polarizing” solutions in patients with acute myocardial infarction: A double-blind study with negative results American Heart Journal. ,vol. 75, pp. 319- 324 ,(1968) , 10.1016/0002-8703(68)90088-4
C Dalton, C Kowalski, Automated colorimetric determination of free fatty acids in biologic fluids. Clinical Chemistry. ,vol. 13, pp. 744- 751 ,(1967) , 10.1093/CLINCHEM/13.9.744
Wells R Moorehead, Edward A Sasse, An Automated Micromethod for Determination of Serum Glucose, with an Improved o-Toluidine Reagent Clinical Chemistry. ,vol. 16, pp. 285- 290 ,(1970) , 10.1093/CLINCHEM/16.4.285
B.L. Pentecost, N.M.C. Mayne, Patricia Lamb, Controlled trial of intravenous glucose, potassium, and insulin in acute myocardial infarction. The Lancet. ,vol. 291, pp. 946- 948 ,(1968) , 10.1016/S0140-6736(68)90903-3
Richard J. Kones, INSULIN, ADENYL CYCLATE, IONS, AND THE HEART Transactions of the New York Academy of Sciences. ,vol. 36, pp. 738- 774 ,(1974) , 10.1111/J.2164-0947.1974.TB01608.X
D. SODI-PALLARES, A. BISTENI, G.A. MEDRANO, M.R. TESTELLI, A. DE MICHELI, The polarizing treatment of acute myocardial infarction. Possibility of its use in other cardiovascular conditions. Chest. ,vol. 43, pp. 424- 432 ,(1963) , 10.1378/CHEST.43.4.424
P.A. Majid, B. Sharma, M.K.M. Meeran, S.H. Taylor, INSULIN AND GLUCOSE IN THE TREATMENT OF HEART-FAILURE The Lancet. ,vol. 300, pp. 937- 941 ,(1972) , 10.1016/S0140-6736(72)92468-3