Antiperspirant activity of H1-histamine blockers as determined by a modified rat foot pad assay.

摘要: A method for inducing sweating in the rat via heat stress and without use of general anesthetics is presented. Five commonly used H1-blocking antihistamines were evaluated this model their antiperspirant efficacy. The ED50 values (µg base/pad) as follows: phenindamine, 3.02; diphenhydramine, 3.25; chlorpheniramine, 3.12; tripelennamine, 4.91; pyrilamine, 13.03. Atropine sulfate, injected into foot pads, was also found to inhibit sweat response. response atropine varied directly with dose. estimated be 0.4 ng base/foot pad. No systemic effects or contralateral involvement seen. pad contains eccrine glands that are innervated by sympathetic cholinergic fibers. This relationship analogous man. data suggest antihistamines, possibly an anticholinergic effect, may useful potential antiperspirants