Behavioral, neuromorphological, and neurobiochemical effects induced by omega-3 fatty acids following basal forebrain cholinergic depletion in aged mice

摘要: In recent years, mechanistic, epidemiologic, and interventional studies have indicated beneficial effects of omega-3 polyunsaturated fatty acids (n-3 PUFA) against brain aging age-related cognitive decline, with the most consistent Alzheimer’s disease (AD) confined especially in early or prodromal stages pathology. present study, we investigated action n-3 PUFA supplementation on behavioral performances hippocampal neurogenesis, volume, astrogliosis aged mice subjected to a selective depletion basal forebrain cholinergic neurons. Such lesion represents valuable model mimic one reliable hallmarks AD neuropathology. Aged first underwent mu-p75-saporin immunotoxin intraventricular lesions obtain massive then were orally supplemented olive oil (as isocaloric control) for 8 weeks. Four weeks after beginning dietary supplementation, anxiety levels as well mnesic, social, depressive-like behaviors evaluated. Subsequently, morphological biochemical analyses quantification carried out. The treatment regulated alterations reverted novelty recognition memory impairment induced by mice. Moreover, preserved enhanced neurogenesis dentate gyrus, reduced hippocampus. Brain positively related mnesic abilities. demonstration that are able counteract deficits neurodegeneration cholinergically depleted promotes their use low-cost, safe nutraceutical tool improve life quality at old age, even presence AD.