Pineal Enzymes: Regulation of Avian Melatonin Synthesis

作者: S. Binkley , S. E. Macbride , D. C. Klein , C. L. Ralph

DOI: 10.1126/SCIENCE.181.4096.273-A

关键词: Acetyltransferase activityEnzymeMethyltransferaseOut of phaseMelatoninMelatonin synthesisEndocrinologyInternal medicineBiology

摘要: Groups of 8-week-old chickens were killed at six time points in their light-dark cycle, and pineal glands removed assayed individually for N- acetyltransferase activity, hydroxyindole -O- methyltransferase melatonin content. The tenfold nocturnal rise was phased identically with the 27-fold increase activity. relatively small changes (20 percent) activity did not appear important causing large melatonin. phase rhythms content relative to cycle qualitatively similar that rats. In contrast, sleep-wake is about 180° out

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