作者: S. Binkley , S. E. Macbride , D. C. Klein , C. L. Ralph
DOI: 10.1126/SCIENCE.181.4096.273-A
关键词: Acetyltransferase activity 、 Enzyme 、 Methyltransferase 、 Out of phase 、 Melatonin 、 Melatonin synthesis 、 Endocrinology 、 Internal medicine 、 Biology
摘要: Groups of 8-week-old chickens were killed at six time points in their light-dark cycle, and pineal glands removed assayed individually for N- acetyltransferase activity, hydroxyindole -O- methyltransferase melatonin content. The tenfold nocturnal rise was phased identically with the 27-fold increase activity. relatively small changes (20 percent) activity did not appear important causing large melatonin. phase rhythms content relative to cycle qualitatively similar that rats. In contrast, sleep-wake is about 180° out