The Croonian Lecture, 1996: endogenous damage to DNA.
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关键词: Cell biology 、 DNA 、 Molecular biology 、 DNA damage 、 Active oxygen 、 DNA repair 、 Human disease 、 Ultraviolet light 、 Endogeny 、 Genome instability 、 Biology
摘要: Although DNA is the carrier of stable genetic information, this giant molecule exhibits slow turnover in cells as a consequence endogenous dam age. lesions result from hydrolysis, and exposure to active oxygen reactive metabolites. These major forms damage heterocyclic bases backbone structure are now well characterized. Most repair enzymes have apparently evolved prevent genomic instability caused by lesions, only exception being those that counteract ultraviolet light inflicted sun. Despite efficiency pathways, some still cause mutagenic alterations may human disease.
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