(diaryl-methyl)-malononitriles and their use as estrogen receptor ligands
作者： Antony Aldo Brazzale , Thomas Joseph Caggiano
DOI:
关键词: Pharmacology 、 Estrogen receptor 、 Biochemistry 、 Chemistry
摘要: The present invention concerns compounds of formula (I) where R1, R2, R3 and R4 are defined in the specification.
google.ca 参考文章(58)
Francine Grodstein, Meir J. Stampfer, JoAnn E. Manson, Postmenopausal Hormone Use and Secondary Prevention of Coronary Events in the Nurses’ Health Study ,(2001)
Smirnoff P, Liel Y, Gnainsky J, Schwartz B, Shany S, The protective effect of estrogen against chemically induced murine colon carcinogenesis is associated with decreased CpG island methylation and increased mRNA and protein expression of the colonic vitamin D receptor. Oncology Research. ,vol. 11, pp. 255- 264 ,(1999)
Christopher A. Teleha, Reginald O. Cann, Denette K. Murphy, Gary A. Cain, Specific salt forms of triphenylethylene derivatives as selective estrogen receptor modulators ,(2001)
Marie C. Phoenixville Chabot-Fletcher, James F. Philadelphia Callahan, Inhibitors of transcription factor nf-kappa b ,(1999)
Larissa L. Zaulyanov, Pattie S. Green, James W. Simpkins, Glutamate receptor requirement for neuronal death from anoxia-reoxygenation: an in Vitro model for assessment of the neuroprotective effects of estrogens. Cellular and Molecular Neurobiology. ,vol. 19, pp. 705- 718 ,(1999) , 10.1023/A:1006948921855
Y Sumida, O Vogl, Functional Polymers. VII. Ethyl 4-Vinyl-α-cyano-β-phenylcinnamate Polymer Journal. ,vol. 13, pp. 521- 536 ,(1981) , 10.1295/POLYMJ.13.521
Hans Ulrich Stilz, Gerhard Jaehne, Bernhard Neises, Olaf Ritzeler, Joerg Habermann, Substituted indoles for modulating nfkb activity ,(2000)
Dena B. Dubal, Paul J. Shughrue, Melinda E. Wilson, Istvan Merchenthaler, Phyllis M. Wise, Estradiol Modulates bcl-2 in Cerebral Ischemia: A Potential Role for Estrogen Receptors The Journal of Neuroscience. ,vol. 19, pp. 6385- 6393 ,(1999) , 10.1523/JNEUROSCI.19-15-06385.1999
Louis Plamondon, Francois Soucy, Alfred L. Goldberg, Peter J. Elliott, Stephen J Brand, Treatment of infarcts ,(1998)
Mary Shire, George Muller, Novel immunotherapeutic agents ,(2002)