Orally available sphingosine 1-phosphate receptor agonists and antagonists
作者： Timothy L. MacDonald , Kevin R. Lynch
DOI:
关键词: Aryl 、 S1P receptor activity 、 Stereochemistry 、 Tautomer 、 Chemistry 、 Alkyl 、 Phosphate 、 Phosphonate 、 Sphingosine-1-phosphate receptor
摘要: The present invention relates to S1P analogs that have activity as receptor modulating agents and the use of such compounds treat diseases associated with inappropriate activity. general structure (I) wherein R 11 is C 5 -C 18 alkyl or alkenyl; Q selected from group consisting 3 6 optionally substituted cycloalkyl, heterocyclic, aryl heteroaryl and; 2 H, 1 4 alkyl, (C alkyl)OH alkyl)NH ; 23 H 15 a phosphonate ester phosphate pharmaceutically acceptable salt tautomer thereof.
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