Effect of sub-chronic ferrous sulfate treatment on motor skills, hematological and biochemical parameters in rats.
作者： Mohamed Ammari , Miryam Elferchichi , Haifa Othman , Mohsen Sakly , Hafedh Abdelmelek
DOI: 10.1080/19338244.2017.1395788
关键词: Peristalsis 、 Mean corpuscular volume 、 Chemistry 、 Endocrinology 、 Sulfate 、 Inflammation 、 Sub chronic 、 Transferrin 、 Internal medicine 、 Ferrous 、 Motor skill
摘要: This study investigated the effects of ferrous sulfate (FeSO4) on motor skills, hematological and biochemical parameters in rats. Adult rats were treated with dose iron (280 mg/L, per os) for 15 consecutive days drinking water. No significant difference was noticed skills stationary beam (p = 0.23) suspended string tests 0.48) between control iron-treated However, showed a increase white blood cells count 0.01), mean corpuscular volume values 0.02) decrease frequency peristaltic contractions fragment intestine (in vitro) compared to 0.01). plasma level 0.89) transferrin amount observed after treatment 0.65). The findings indicate that at 280 mg/L, os adult induced (sign potential inflammation), but not deficit.
sci-hub.se 参考文章(40)
P. Nielsen, U. Kordes, R. Fischer, R. Engelhardt, G. E. Janka, SQUID-Biosuszeptometrie bei Eisenüberladungskrankheiten in der Hämatologie Klinische Padiatrie. ,vol. 214, pp. 218- 222 ,(2002) , 10.1055/S-2002-33186
Ningning Zhao, Caroline A. Enns, Iron Transport Machinery of Human Cells: Players and Their Interactions Current Topics in Membranes. ,vol. 69, pp. 67- 93 ,(2012) , 10.1016/B978-0-12-394390-3.00003-3
John W Eaton, Mingwei Qian, Molecular bases of cellular iron toxicity12 1Guest Editor: Mario Comporti 2This article is part of a series of reviews on “Iron and Cellular Redox Status.” The full list of papers may be found on the homepage of the journal. Free Radical Biology and Medicine. ,vol. 32, pp. 833- 840 ,(2002) , 10.1016/S0891-5849(02)00772-4
Yuanyuan Qin, Wenzhen Zhu, Chuanjia Zhan, Lingyun Zhao, Jianzhi Wang, Qing Tian, Wei Wang, Investigation on positive correlation of increased brain iron deposition with cognitive impairment in Alzheimer disease by using quantitative MR R2′ mapping Journal of Huazhong University of Science and Technology [Medical Sciences]. ,vol. 31, pp. 578- 585 ,(2011) , 10.1007/S11596-011-0493-1
Matthias W Hentze, Martina U Muckenthaler, Nancy C Andrews, Balancing Acts: Molecular Control of Mammalian Iron Metabolism Cell. ,vol. 117, pp. 285- 297 ,(2004) , 10.1016/S0092-8674(04)00343-5
Jailane de Souza Aquino, Renata Leite Tavares, Larissa de Brito Medeiros, Camila Cândida de Lima Martins, Débora Catarine Nepomuceno de Pontes Pessoa, Tânia Lúcia Montenegro Stamford, Effect of the consumption on buriti oil on the metabolism of rats induced by iron overload Archives of Endocrinology and Metabolism. ,vol. 59, pp. 422- 427 ,(2015) , 10.1590/2359-3997000000105
Lindsay H. Allen, Iron Supplements: Scientific Issues Concerning Efficacy and Implications for Research and Programs Journal of Nutrition. ,vol. 132, pp. 813- 819 ,(2002) , 10.1093/JN/132.4.813S
W. Chen, P. N. Paradkar, L. Li, E. L. Pierce, N. B. Langer, N. Takahashi-Makise, B. B. Hyde, O. S. Shirihai, D. M. Ward, J. Kaplan, B. H. Paw, Abcb10 physically interacts with mitoferrin-1 (Slc25a37) to enhance its stability and function in the erythroid mitochondria Proceedings of the National Academy of Sciences of the United States of America. ,vol. 106, pp. 16263- 16268 ,(2009) , 10.1073/PNAS.0904519106
A. Fredriksson, N. Schröder, T. Archer, Neurobehavioural deficits following postnatal iron overload: I spontaneous motor activity. Neurotoxicity Research. ,vol. 5, pp. 53- 76 ,(2003) , 10.1007/BF03033373
Karima Maaroufi, Mohamed Ammari, Mustapha Jeljeli, Vincent Roy, Mohsen Sakly, Hafedh Abdelmelek, Impairment of emotional behavior and spatial learning in adult Wistar rats by ferrous sulfate Physiology & Behavior. ,vol. 96, pp. 343- 349 ,(2009) , 10.1016/J.PHYSBEH.2008.10.019