Effect of Tulbaghia violacea on the blood pressure and heart rate in male spontaneously hypertensive Wistar rats.

作者: Ismaila A. Raji , Pierre Mugabo , Kenechukwu Obikeze

DOI: 10.1016/J.JEP.2011.12.034

关键词: Angiotensin-converting enzymeEndocrinologyDobutamine HydrochlorideInternal medicineTulbaghia violaceaMedicinePhenylephrineAngiotensin IIPhenylephrine HydrochlorideBlood pressureAngiotensin receptor

摘要: Abstract Ethnopharmacological relevance Tulbaghia violacea Harv. (Alliaceae) is a small bulbous herb which belongs to the family Alliaceae, most commonly associated with onions and garlic. In South Africa, this has been traditionally used in treatment of various ailments, including fever, colds, asthma, paralysis, hypertension stomach problems. The aim study was evaluate effect methanol leaf extracts (MLE) on blood pressure (BP) heart rate (HR) anaesthetized male spontaneously hypertensive rats; find out mechanism(s) by it acts. Materials methods MLE (5–150 mg/kg), angiotensin I human acetate salt hydrate (ang I, 3.1–100 μg/kg), II II, 3.1–50 μg/kg), phenylephrine hydrochloride (phenylephrine, 0.01–0.16 mg/kg) dobutamine (dobutamine, 0.2–10.0 μg/kg) were infused intravenously, while BP HR measured via transducer connecting femoral artery Powerlab. Results significantly ( p (60 mg/kg). However, co-infusion ang or (60 mg/kg) did not produce any significant change when compared infusion either agent alone same animal. Conclusions reduced SHR. reduction may be due actions converting enzyme (ACE) β 1 adrenoceptors.

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