The medicinal uses, toxicities and anti-inflammatory activity of Polyalthia species (Annonaceae).

摘要: Abstract Ethnopharmacological relevance Polyalthia is one of the largest and notable genera in Annonaceae family. species have been widely used folklore medicine for treatment rheumatic fever, gastrointestinal ulcer generalized body pain. Numerous vitro vivo studies on Species also corroborated significant anti-inflammatory potential its extracts secondary metabolites. Aim study This review an attempt to assess activity by giving critical appraisal establishing evidences their traditional uses. Moreover this will highlight lead compounds future drug development that can serve as a with comparative efficacy minimum side effects. Materials methods An extensive literature review, focusing was conducted using following databases:PubMed, ScienceDirect, SpringerLink, Ovid, Scopus ProQuest, well locally available books, journals relevant documents. The reference lists retrieved papers were searched additional studies. Results shown through various mechanism action. most includes inhibition nuclear factor kappa B (NF-κB), prostaglandins (PGs), pro-inflammatory cytokines, inducible nitric oxide synthase (iNOS) reactive oxygen (ROS). data suggests hydroxycleroda-3,13-dien-15,16-olide 16-oxocleroda-3,13-dien-15-oic acid, quercetin, rutin, spinasterol, α-spinasterol, goniothalamin (−)−5-hydroxygoniothalamin are potent from comparable IC50 positive controls. Conclusions pharmacological supported use against pain, haemorrhages inflammation medicine. Flavonoids, diterpenoids, sterols styrylpyrones genus class activity. Secondary metabolites these classes should be brought into further research fill gaps knowledge pharmacokinetics, pharmacodynamics, bioavailability, toxicity order convert pre-clinical results clinical investigation.