Persistence of cerebral metabolic abnormalities in chronic schizophrenia as determined by positron emission tomography.

摘要: Local cerebral metabolic rates were determined by positron emission tomography and the deoxyglucose method in a group of 10 chronic schizophrenic subjects before after somatic treatment eight normal subjects. Before treatment, had markedly lower absolute activity than did controls both frontal temporal regions trend toward relative hyperactivity basal ganglia area. After their approached those seen nearly all except frontal. Persistence diminished metabolism was manifested as significant hypofrontality. These findings suggest specific loci aberrant functioning schizophrenia utility characterizing these abnormalities.