The actin cytoskeleton and mast cell function

摘要: The application of high and super-resolution microscopy techniques has extended the possibilities studying actin dynamics in mast cells (MCs). These studies demonstrated close correlation between actin-driven changes cell morphology functions that MC perform during their life cycle. Dynamic conversions polymerization depolymerization support degranulation leading to release preformed, secretory granule (SG)-contained, inflammatory mediators. Cell flattening inflicting an porous geometry clearing cortical actin, characterize phenotype. In contrast, pericentral clusters, entrap SGs, migratory phenotype, which supports migration, but restricts degranulation. Multiple binding interacting proteins regulate these rearrangements, compliance with signals elicited by respective activating receptors. Here, we review recent findings on interplay cytoskeleton migration