Gastric cancer: an infectious disease

摘要: Although viral and parasitic agents have been implicated in human cancers, gastric cancer is currently the only malignant neoplasia recognized as causally associated humans with a bacterium. In 1994, International Agency for Research on Cancer (IARC) concluded that “there sufficient evidence carcinogenicity of infection Helicobacter pylori.” At time, they inadequate experimental animals Since then, has documented, especially using Mongolian gerbil model. 2009, was reevaluated confirmed by IARC. H pylori causation adenocarcinoma mucosa–associated lymphoid tissue lymphoma. Because adenocarcinomas account more than 90% all malignancies, this review focuses adenocarcinomas. rates decreasing many countries, disease second most common cause death from worldwide ranks fourth incidence (Table 1). Approximately 1 million new cases were estimated 2007. There are marked differences among populations worldwide. The highest incidences Japan, Korea, China, eastern Europe, Andean portions Latin America. Lower seen Africa, Oceania, North America, Brazil (Fig. Despite low overall mortality United States, there some ethnic groups at increased risk, including African Americans, Native immigrants east Asia addition, although steadily declining recent observational study based data National Institute’s Surveillance, Epidemiology,