A Novel Biopolymer Nano-Complex Based on Fish Scale Collagen, Konjac Glucomannan, Camellia Chrysantha Polyphenols and Ginsenoside Rb1: Preparation, Characterization and Its Bioactivity
作者： Dai Quang Ngo , Thuy Chinh Nguyen , Tien Dung Nguyen , Thi Lan Phung , Quoc Trung Vu
DOI: 10.1007/S10924-020-02022-0
关键词: Polyphenol 、 Dynamic light scattering 、 Biopolymer 、 Antioxidant 、 Materials science 、 Infrared spectroscopy 、 Fish scale 、 Buffer solution 、 Camellia chrysantha 、 Nuclear chemistry
摘要: A nano-complex containing fish scale collagen, konjac glucomannan, camellia chrysantha polyphenols and ginsenoside Rb1 (GCPR) have been prepared successfully by gelation method. Infrared spectroscopy (IR), scanning field emission electron microscopy (FESEM), Energy-dispersive X-ray (EDX), dynamic light scattering (DLS), ultraviolet–visible (UV–Vis) were used to determine characteristics of obtained GCPR nano-complex. The is in spherical shape with the average particle size 115.4 nm (95.1%) 593.0 nm (4.1%). Polyphenols could interact collagen glucomannan through hydrogen bonding dipole–dipole interactions, therefore, drug release from pH 2 buffer solution (simulated gastric fluid human body) 7.4 intestinal be controlled. In particular, biological activity inhibition cancer cells, anti-inflammatory antioxidant also was investigated. results show that exhibits a positive effect on cells comparison polyphenol or Rb1. Besides, exhibit non-toxic normal antioxidation ability. This promising for application biomedicine.
springer.com
sci-hub.st 参考文章(63)
Davy CW Lee, Allan SY Lau, Effects of Panax ginseng on tumor necrosis factor-α-mediated inflammation: a mini-review. Molecules. ,vol. 16, pp. 2802- 2816 ,(2011) , 10.3390/MOLECULES16042802
Lixia Song, Xiangshe Wang, Xueqin Zheng, Dejian Huang, Polyphenolic antioxidant profiles of yellow camellia Food Chemistry. ,vol. 129, pp. 351- 357 ,(2011) , 10.1016/J.FOODCHEM.2011.04.083
Anoja S Attele, Ji An Wu, Chun-Su Yuan, Ginseng pharmacology: Multiple constituents and multiple actions Biochemical Pharmacology. ,vol. 58, pp. 1685- 1693 ,(1999) , 10.1016/S0006-2952(99)00212-9
Qing Yuan, Yan-wen Jiang, Ting-ting Ma, Qiu-hong Fang, Lei Pan, Attenuating effect of Ginsenoside Rb1 on LPS-induced lung injury in rats. Journal of Inflammation. ,vol. 11, pp. 40- 40 ,(2014) , 10.1186/S12950-014-0040-5
Tim Mosmann, Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays Journal of Immunological Methods. ,vol. 65, pp. 55- 63 ,(1983) , 10.1016/0022-1759(83)90303-4
Jane V. Higdon, Balz Frei, Tea catechins and polyphenols: health effects, metabolism, and antioxidant functions. Critical Reviews in Food Science and Nutrition. ,vol. 43, pp. 89- 143 ,(2003) , 10.1080/10408690390826464
Jin-Bin Wei, Xiong Li, Hui Song, Yong-Hong Liang, Yu-Zheng Pan, Jun-Xiang Ruan, Xia Qin, Yong-Xin Chen, Cai-Li Nong, Zhi-Heng Su, Characterization and determination of antioxidant components in the leaves of Camellia chrysantha (Hu) Tuyama based on composition–activity relationship approach Journal of Food and Drug Analysis. ,vol. 23, pp. 40- 48 ,(2015) , 10.1016/J.JFDA.2014.02.003
Qi Zhou, Lei Jiang, Chunhua Xu, Dongjiao Luo, Chunlai Zeng, Pu Liu, Ming Yue, Yangyang Liu, Xiaosheng Hu, Hu Hu, Ginsenoside Rg1 inhibits platelet activation and arterial thrombosis. Thrombosis Research. ,vol. 133, pp. 57- 65 ,(2014) , 10.1016/J.THROMRES.2013.10.032
Kai Marxen, Klaus Vanselow, Sebastian Lippemeier, Ralf Hintze, Andreas Ruser, Ulf-Peter Hansen, Determination of DPPH Radical Oxidation Caused by Methanolic Extracts of Some Microalgal Species by Linear Regression Analysis of Spectrophotometric Measurements Sensors. ,vol. 7, pp. 2080- 2095 ,(2007) , 10.3390/S7102080
Rajamanickam Baskar, Kuo Ann Lee, Richard Yeo, Kheng-Wei Yeoh, Cancer and Radiation Therapy: Current Advances and Future Directions International Journal of Medical Sciences. ,vol. 9, pp. 193- 199 ,(2012) , 10.7150/IJMS.3635