Five fold increase of insulin concentration delays the absorption of subcutaneously injected human insulin suspensions in pigs

摘要: Human NPH U100 (100 IU/ml), given once daily, is often absorbed too fast to cover the basal insulin demand throughout 24 h. The aim of present study was examine whether absorption human suspensions would be delayed by increasing concentration from U500. In each experiment 10 IU corresponding Ul00 and U500 preparations, labelled with 125I-insulin, were injected subcutaneously contralaterally in neck a pig followed monitoring residual radioactivity over injection sites. time until 75, 50 25% (T(75%), T(50%) T(25%)) using compared 14 experiments: T(75%): 5.0+/-0.5 (mean+/-SEM) vs 3.8+/-0.3 h (P=0.007, paired t-test), T(50%): 12. 2+/-0.9 9.0+/-0.6 (P=0.003) T(25%). 24.2+/-1.2 17.9+/-1. 2 (P=0.001). values for semilente eight experiments were: 2.8+/-0.4 1.6+/-0.2 (P=0.02), 5.6+/-0.6 3.4+/-0.3 (P=0.01) T(25%): 10.9+/-1.1 7.2+/-0.7 (P=0.009). Thus, dose or pigs substantially changing appears more appropriate than daily therapy.