Chapter 17. Antiviral Agents
作者： Samuel Baron , George Galasso
DOI: 10.1016/S0065-7743(08)61005-2
关键词: Keratoconjunctivitis 、 Virology 、 Keratitis 、 Ribavirin 、 Amantadine 、 Idoxuridine 、 Deoxyuridine 、 In vivo 、 Medicine 、 Interferon inducer
摘要: Publisher Summary This chapter discusses various interferon inducers, such as idoxuridine, cytosine arabinoside (Ara-C or 1-β-D-arabinofuranosyl cytosine), adenine (Ara-A), amantadine, ribavirin, disodium phosphonoacetate (PAA), and 2-Deoxy-D glucose (2-D-G). The topical application of 5-iodo-2'-deoxyuridine (idoxuridine, IDU) has been shown to be efficacious in the treatment herpetic keratoconjunctivitis is current choice. Ara-C found have vitro activity against herpes viruses, pox-viruses rhabdoviruses. Amantadine used extensively for Parkinson's disease, with only livedo reticularis mild ankle edema seen additional adverse effects. Another broad- spectrum anti viral clinical potential 1-β-D-ribofuranoxyl-1; 2, 4-triazole-3-carboxamide (ribavirin, Virazole). Disodium Phosphonoacetate (PAA) highly promising antiviral compound was effective HVH types 1 2 tissue culture subsequently confirmed vivo dermatitis mice keratitis rabbits. 2-D-G sugar analog preventing reducing severity
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