Molecular Oncogenesis of Lung Cancer
作者： Arwen A. Stelter , Jingwu Xie
DOI: 10.1007/978-0-387-72430-0_16
关键词: Lung cancer 、 Breast cancer 、 Prostate cancer 、 Carcinogenesis 、 Medicine 、 Oncology 、 Disease 、 Cancer 、 Internal medicine 、 Colorectal cancer 、 Metastasis
摘要: In 2005, cancer surpassed heart disease as the leading cause for death in Americans under age of 80 years. Among all types human cancer, lung is cancer-related death, claiming more than 150,000 lives every year United States alone (which exceeds combined mortality from breast, prostate, colorectal, and pancreatic cancers). Patients with advanced stages representing 75% new cases, have a median survival time only 10 months.1 contrast to significant medical burden associated research on underfunded. According National Institutes Health data (http://planning.cancer.gov/disease), U.S. government spent approximately $1,200 per 2002 compared $11,425 breast $8,190 prostate $3,350 colorectal cancer. Approximately $31,000 was HIV/AIDS 2002. Understanding molecular basis progression tumor metastasis an essential step reducing
springer.com
sci-hub.st 参考文章(46)
Mohammed El-Mahdy, Sundaresan Venkatachalam, Qianzheng Zhu, Manzoor A. Wani, Altaf A. Wani, Enhanced Sensitivity to anti-Benzo(a)pyrene-diol-epoxide DNA Damage Correlates with Decreased Global Genomic Repair Attributable to Abrogated p53 Function in Human Cells Cancer Research. ,vol. 60, pp. 2273- 2280 ,(2000)
Leisa Johnson, Kim Mercer, Doron Greenbaum, Roderick T. Bronson, Denise Crowley, David A. Tuveson, Tyler Jacks, Somatic activation of the K-ras oncogene causes early onset lung cancer in mice Nature. ,vol. 410, pp. 1111- 1116 ,(2001) , 10.1038/35074129
Sabine Zöchbauer-Müller, John D. Minna, Adi F. Gazdar, Kwun Fong, Molecular pathogenesis of lung cancer and potential translational applications Cancer Journal. ,vol. 8, ,(2002)
Deshan Yu, Jesse A. Berlin, Trevor M. Penning, Jeffrey Field, Reactive oxygen species generated by PAH o-quinones cause change-in-function mutations in p53. Chemical Research in Toxicology. ,vol. 15, pp. 832- 842 ,(2002) , 10.1021/TX010177M
Isao Ito, Lin Ji, Fumihiro Tanaka, Yuji Saito, Began Gopalan, Cynthia D Branch, Kai Xu, E Neely Atkinson, Benjamin N Bekele, L Clifton Stephens, John D Minna, Jack A Roth, Rajagopal Ramesh, Liposomal vector mediated delivery of the 3p FUS1 gene demonstrates potent antitumor activity against human lung cancer in vivo Cancer Gene Therapy. ,vol. 11, pp. 733- 739 ,(2004) , 10.1038/SJ.CGT.7700756
Hisayuki Shigematsu, Adi F. Gazdar, Somatic mutations of epidermal growth factor receptor signaling pathway in lung cancers International Journal of Cancer. ,vol. 118, pp. 257- 262 ,(2006) , 10.1002/IJC.21496
Béatrice Eymin, Sylvie Gazzeri, Christian Brambilla, Elisabeth Brambilla, Mdm2 overexpression and p14(ARF) inactivation are two mutually exclusive events in primary human lung tumors. Oncogene. ,vol. 21, pp. 2750- 2761 ,(2002) , 10.1038/SJ.ONC.1205359
C Mascaux, N Iannino, B Martin, M Paesmans, T Berghmans, M Dusart, A Haller, P Lothaire, A-P Meert, S Noel, J-J Lafitte, J-P Sculier, The role of RAS oncogene in survival of patients with lung cancer: a systematic review of the literature with meta-analysis British Journal of Cancer. ,vol. 92, pp. 131- 139 ,(2005) , 10.1038/SJ.BJC.6602258
Clifton F. Mountain, Revisions in the International System for Staging Lung Cancer Chest. ,vol. 111, pp. 1710- 1717 ,(1997) , 10.1378/CHEST.111.6.1710
S RODIN, A RODIN, Origins and selection of p53 mutations in lung carcinogenesis. Seminars in Cancer Biology. ,vol. 15, pp. 103- 112 ,(2005) , 10.1016/J.SEMCANCER.2004.08.005