Pembrolizumab for metastatic adrenocortical carcinoma with high mutational burden: Two case reports

作者: Jose Mauricio Mota , Luana Guimarães Sousa , Maria Ignez Braghiroli , Luiz Tenório Siqueira , João Evangelista Bezerra Neto

DOI: 10.1097/MD.0000000000013517

关键词: MitotaneAdrenocortical carcinomaOncologyInternal medicineDiseaseMetastatic Adrenocortical CarcinomaAntibodyMutation (genetic algorithm)MedicineMonoclonalPembrolizumab

摘要: AbstractRationale:In the setting of metastatic or locally advanced adrenocortical carcinoma, a limited number therapies are available and their efficacy is generally below modest. The backbone treatment remains surgery, even for disease, whenever it possible, mitotane. Chemot

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