The efficacy, safety and cost-effectiveness of intra-operative cell salvage in high-bleeding-risk cardiac surgery with cardiopulmonary bypass: a prospective randomized and controlled trial.

摘要: Objective: Intra-operative cell salvage (CS) was reported to be ineffective, safe and not cost-effective in low-bleeding-risk cardiac surgery with cardiopulmonary bypass (CPB), but studies high-bleeding-risk are limited. The objective of this study is evaluate the efficacy, safety cost-effectiveness intra-operative CS CPB. Methods: One hundred fifty patients were randomly assigned either group (Group CS) or without C). Study endpoints defined as perioperative allogeneic red blood (RBC) transfusion, impairment coagulative function, postoperative adverse events costs transfusion-related. Results: Both proportion quantity RBC transfusion significantly lower Group than that C (p=0.0002, <0.0001, respectively). incidence residual heparin total function 24 hours after surgery, excessive bleeding, higher (p=0.018, 0.042, 0.034, Cost both (p<0.001, =0.002, (p =0.001). Conclusion: CPB effective, generally safe, developed countries China.