CoCl2·6H2O or LaCl3·7H2O Catalyzed Biginelli Reaction. One‐Pot Synthesis of 3,4‐Dihydropyrimidin‐2(1H)‐ones
作者： Jun Lu , Yin-Juan Bai , Yan-Hong Guo , Zhen-Jun Wang , Huai-Rang Ma
关键词: Ethanol 、 Chloride 、 Chemistry 、 Aldehyde 、 Lanthanum 、 Catalysis 、 One-pot synthesis 、 Urea 、 Inorganic chemistry 、 Biginelli reaction 、 Organic chemistry
摘要: An efficient synthesis of 3,4-dihydropyrimidinones from aldehyde, β-keto ester and urea in ethanol using cobalt chloride hexahydrate or lanthanum heptahydrate as a catalyst was described. Compared to the classical Biginelli reaction, this new method consistently has advantage good yields (56%-99%) well short reaction time (4–5 h).
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