Apoptosis and Angiogenesis in Cancer Prevention by Selenium

摘要: Epidemiological and laboratory findings have long implicated a potential anti-cancer activity of the trace element nutrient selenium (Se). Note that it is often for convenience reasons to describe such in terms element. A vast volume data been accumulated supporting theme cancer preventive expressed as function dose chemical form which resides, not elemental Se per se (1,2). The landmark prevention trial by Clark, Combs coworkers demonstrated first time supra-nutritional supplement (provided selenized yeast) US skin patient population otherwise adequate nutrition might be an effective agent several major human epithelial cancers (3). With profound public health implications at stake, many serious issues demand clear understanding mechanisms through exerts activity. Some these pressing questions, example, include what form(s) doses should used? What populations given intervention? How intervention given?