Epigenetic regulation of DNA repair machinery inHelicobacter pylori-induced gastric carcinogenesis
作者： Juliana Carvalho Santos , Marcelo Lima Ribeiro
关键词: Biology 、 DNA repair 、 Epigenetics 、 DNA damage 、 DNA methylation 、 DNA 、 Cancer 、 Carcinogenesis 、 Histone 、 Cancer research 、 Gastroenterology 、 General Medicine
摘要: Although thousands of DNA damaging events occur in each cell every day, efficient repair pathways have evolved to counteract them. The machinery plays a key role maintaining genomic stability by avoiding the maintenance mutations. enzymes continuously monitor chromosomes correct any damage that is caused exogenous and endogenous mutagens. If proliferating cells not repaired because an inadequate expression genes, it might increase risk cancer. In addition mutations, which can be either inherited or somatically acquired, epigenetic silencing genes has been associated with carcinogenesis. Gastric cancer represents second highest cause mortality worldwide. disease develops from accumulation several genetic changes during lifetime. Among factors, Helicobacter pylori (H. pylori) infection considered main driving factor gastric development. Thus, this review, we summarize current knowledge H. on regulation
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