Extracorporeal Endotoxin Removal For The Treatment of Sepsis:Endotoxin Adsorption Cartridge (Toraymyxin)
作者： Hisataka Shoji
DOI: 10.1046/J.1526-0968.2003.00005.X
关键词: Systemic inflammatory response syndrome 、 Extracorporeal 、 Anesthesia 、 Sepsis 、 Hemodynamics 、 Medicine 、 Septic shock 、 Polymyxin B 、 National health insurance 、 Endotoxin removal
摘要: Toray Industries Inc. has developed an endotoxin removal cartridge (Toraymyxin) composed of a polymyxin B immobilized, fibrous adsorbent. Toraymyxin been listed as blood purification medical device for to be reimbursed by the Japanese national health insurance since 1994. can applied patients with endotoxemia or suspected gram-negative infection, which fulfilll conditions Systemic Inflammatory Response Syndrome (SIRS) and have septic shock demanding vasopressor infusion. Since 1994, over 30,000 received this treatment. The safety confirmed improvement hemodynamic dysfunction shown major benefit. Infection resulting from acute abdominal condition requiring surgery one good indications Toraymyxin. Further studies are now ongoing establish treatment options treat sepsis clarify mechanisms involved in therapy.
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